Article

Germline <i>de novo</i> mutation clusters arise during oocyte aging in genomic regions with increased double-strand break incidence

2017-05-27

Abstract excerpt

Clustering of mutations has been found both in somatic mutations from cancer genomes and in germline de novo mutations (DNMs). We identified 1,755 clustered DNMs (cDNMs) within whole-genome sequencing data from 1,291 parent-offspring trios and investigated the underlying mutational mechanisms. We found that the number of clusters on the maternalallele was positively correlated with maternal age and that these con...

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Literature Corpus work: d7701109-d406-5b52-b989-0b53b1ccd88c
DOI: 10.1101/140111

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