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The development of a mathematical modelling framework to translate TB vaccine responses between species and predict the most immunogenic dose in humans using animal data

2018-01-01

Abstract excerpt

Background: Preclinical animal experiments measuring vaccine immunogenicity and safety are essential, not only to establish if the vaccine should progress further, but to generate information on how the vaccine should be administered in humans. Animal models that represent human vaccine responses well are vital to translate information about vaccine dose to clinical phases. Vaccine dose is a key aspect in creating...

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Literature Corpus work
d745bbe7-99e4-5bbe-b289-3a19427b9d21
DOI
10.17037/pubs.04647153
Open publication

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The development of a mathematical modelling framework to translate TB vaccine responses between species and predict the most immunogenic dose in humans using animal dataDOI 10.17037/pubs.04647153
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