Article
Adoptive transfer of ex vivo expanded Vγ9Vδ2 T cells in combination with zoledronic acid inhibits cancer growth and limits osteolysis in a murine model of osteolytic breast cancer.
Cancer letters - 1 Feb 2017
Zysk Aneta, DeNichilo Mark O, Panagopoulos Vasilios, Zinonos Irene, Liapis Vasilios, Hay Shelley, Ingman Wendy, Ponomarev Vladimir, Atkins Gerald, Findlay David, Zannettino Andrew, Evdokiou Andreas
Abstract excerpt
Bone metastases occur in over 75% of patients with advanced breast cancer and are responsible for high levels of morbidity and mortality. In this study, ex vivo expanded cytotoxic Vγ9Vδ2 T cells isolated from human peripheral blood were tested for their anti-cancer efficacy in combination with zoledronic acid (ZOL), using a mouse model of osteolytic breast cancer. In vitro, expanded Vγ9Vδ2 T cells were cytotoxic...
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