Article

Proposed Mechanisms of Existential Resilience: A Heuristic Framework Integrating Free Energy Principle, Affective Criticality, and Spatiotemporal Neuroscience

2026-01-20

Abstract excerpt

<h4>Background: </h4> Contemporary psychiatry has achieved unprecedented neurobiological precision in understanding symptom-level mechanisms, yet clinical outcomes remain stagnant—depression prevalence unchanged, suicide rates rising, and patients frequently reporting existential emptiness despite achieving symptom remission. This paradox suggests a fundamental theoretical gap: psychiatry lacks a scientific langua...

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Literature Corpus work: 77db5f19-dc9c-5d22-ab8a-4e740fc632b9
DOI: 10.20944/preprints202601.1426.v1

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