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Subcutaneous adipose tissue-secreted proteins as endocrine regulators of physical and cognitive function in older adults

15 Jul 2025

Abstract excerpt

Declines in skeletal muscle and cognitive function in older adults have been linked to abnormalities in abdominal subcutaneous adipose tissue (ASAT), yet the underlying molecular mediators remain poorly understood. Here, leveraging ASAT transcriptomics and explant-conditioned media proteomics from participants in the Study of Muscle, Mobility and Aging (SOMMA; age ≥70 years, n = 229), we identified ASAT gene...

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Share to Adipokines, Inflammation, and Metabolic Diseases
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PMID: 40675551
DOI: 10.1016/j.molmet.2025.102213

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