Article

Partially differentiated enterocytes in ileal and distal-colonic human F508del-CF-enteroids secrete fluid in response to forskolin and linaclotide

2025-02-08

Abstract excerpt

<h4>SUMMARY</h4> Constipation causes significant morbidity in Cystic Fibrosis (CF) patients. Using CF patient (F508del) derived ex vivo ileal and distal colonic/rectal enteroids as a model and the Forskolin Induced Swelling Assay (FIS), we compared CFTR mediated fluid secretion in human enterocytes across the crypt-villus axis. CFTR expression and FIS decreased as enterocytes differentiated from crypt to become...

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Literature Corpus work: d6b203f9-40b6-5ea1-9fed-29447df9dfd3
DOI: 10.1101/2025.02.03.636268

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Partially differentiated enterocytes in ileal and distal-colonic human F508del-CF-enteroids secrete fluid in response to forskolin and linaclotideDOI 10.1101/2025.02.03.636268Read

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