Article
Forskolin-induced organoid swelling is associated with long-term cystic fibrosis disease progression.
The European respiratory journal - 1 Aug 2022
Muilwijk Danya, de Poel Eyleen, van Mourik Peter, Suen Sylvia W F, Vonk Annelotte M, Brunsveld Jesse E, Kruisselbrink Evelien, Oppelaar Hugo, Hagemeijer Marne C, Berkers Gitte, de Winter-de Groot Karin M, Heida-Michel Sabine, Jans Stephan R, van Panhuis Hannah, van der Eerden Menno M, van der Meer Renske, Roukema Jolt, Dompeling Edward, Weersink Els J M, Koppelman Gerard H, Vries Robert, Zomer-van Ommen Domenique D, Eijkemans Marinus J C, van der Ent Cornelis K, Beekman Jeffrey M
Abstract excerpt
RATIONALE: Cystic fibrosis (CF) is a monogenic life-shortening disease associated with highly variable individual disease progression which is difficult to predict. Here we assessed the association of forskolin-induced swelling (FIS) of patient-derived organoids with long-term CF disease progression in multiple organs and compared FIS with the golden standard biomarker sweat chloride concentration (SCC). METHODS:...
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