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Targeted integration of EpCAM-specific CAR in human induced pluripotent stem cells and their differentiation into NK cells

21 Nov 2021

Abstract excerpt

BACKGROUND: Redirection of natural killer (NK) cells with chimeric antigen receptors (CAR) is attractive in developing off-the-shelf CAR therapeutics for cancer treatment. However, the site-specific integration of a CAR gene into NK cells remains challenging. METHODS: In the present study, we genetically modified human induced pluripotent stem cells (iPSCs) with a zinc finger nuclease (ZFN) technology to...

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PMID: 34802459
DOI: 10.1186/s13287-021-02648-4

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