Article

Identification of cellular double-stranded RNAs in mammalian embryonic stem cells

2026-04-15

Abstract excerpt

Antiviral defence mechanisms are typically activated upon sensing virus-derived nucleic acids. During replication, viruses generate double-stranded RNA (dsRNA) intermediates that the innate immune system can sense, triggering several defence pathways. Conversely, mammalian cells avoid accumulating their own endogenous dsRNA to prevent activating these defence mechanisms. However, we demonstrate that mammalian embr...

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Literature Corpus work: d6a53497-3a20-50a0-a916-5631a8c7a56a
DOI: 10.64898/2026.04.13.718158

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