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An ancient fecundability-associated polymorphism creates a new GATA2 binding site in a distal enhancer of <i>HLA-F</i>

2018-01-08

Abstract excerpt

Variation in female reproductive traits such as fertility, fecundity, and fecundability are heritable in humans, but identifying and functionally characterizing genetic variants associated with these traits has been challenging. Here we explore the functional significance and evolutionary history of a G/A polymorphism of SNP rs2523393, which we have previously shown is an eQTL for the HLA-F gene and significantly...

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Literature Corpus work
d6982648-33d1-5636-a39a-57941636cad8
DOI
10.1101/245043
Open publication

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