An Ancient Fecundability-Associated Polymorphism Switches a Repressor into an Enhancer of Endometrial TAP2 Expression.

doi:10.1016/j.ajhg.2016.09.002

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Article

An Ancient Fecundability-Associated Polymorphism Switches a Repressor into an Enhancer of Endometrial TAP2 Expression.

American journal of human genetics - 3 Nov 2016

Mika Katelyn M, Lynch Vincent J

Abstract excerpt

Variation in female reproductive traits, such as fertility, fecundity, and fecundability, is heritable in humans, but identifying and functionally characterizing genetic variants associated with these traits has been challenging. Here, we explore the functional significance and evolutionary history of a T/C polymorphism of SNP rs2071473, which we have previously shown is an eQTL for TAP2 and significantly...

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PMID: 27745831
DOI: 10.1016/j.ajhg.2016.09.002
PMCID: PMC5097936

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TAP2

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