Article

Development of conditional-siRNA programmable riboswitch for targeting adverse cardiac remodeling

2025-01-16

Abstract excerpt

<h4>ABSTRACT</h4> Heart Failure (HF) remains a global epidemic and a significant healthcare burden, with an unmet need for novel therapies to target the preceding pathological hypertrophy in vulnerable patients. Here we report the development of novel conditional-siRNA ( Cond- siRNA) constructs that are selectively activated by disease-specific RNA biomarkers to enable cell-specific inhibition of a target diseas...

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Literature Corpus work: d6958b81-cf04-592d-afe3-3c7ad6df30d0
DOI: 10.1101/2025.01.16.633434

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