Article

<i>In Vivo</i> Rescue of Cardiomyopathy Through Cardiac Prime Editing

2026-02-12

Abstract excerpt

<h4>ABSTRACT</h4> Heart disease affects millions of individuals and prime editing (PE) may enable curative therapies that address the underlying drivers of heart disease. Here we describe the establishment and optimization of an in vivo cardiac PE platform which mediates efficient editing in the heart with no detectable editing in the liver. We performed a proof-of-concept test on RNA binding motif protein 20 (...

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Literature Corpus work: 325bebad-7cb2-5bc1-9735-da29a1ff5c3e
DOI: 10.64898/2026.02.10.705148

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