Article

Cas13b-mediated RNA targeted therapy alleviates genetic dilated cardiomyopathy in mice

2023-06-12

Abstract excerpt

<title>Abstract</title> <p>Background Recent advances in gene editing technology have opened up new avenues for <italic>in vivo</italic> gene therapy, which holds great promise as a potential treatment method for dilated cardiomyopathy (DCM). The CRISPR-Cas13 system has been shown to be an effective tool for knocking down RNA expression in mammalian cells. Results In this study, we delivered PspCas13b with <ita...

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Literature Corpus work: 2075494a-5c85-596c-a18e-a66e94ee1392
DOI: 10.21203/rs.3.rs-2944961/v1

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