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Article

Sumoylation-independent activation of Calcineurin-NFAT-signaling via SUMO2 mediates cardiomyocyte hypertrophy.

Scientific reports - 21 Oct 2016

Bernt Alexander, Rangrez Ashraf Y, Eden Matthias, Jungmann Andreas, Katz Sylvia, Rohr Claudia, Müller Oliver J, Katus Hugo A, Sossalla Samuel T, Williams Tatjana, Ritter Oliver, Frank Derk, Frey Norbert

Abstract excerpt

The objective of this study was to identify unknown modulators of Calcineurin (Cn)-NFAT signaling. Measurement of NFAT reporter driven luciferase activity was therefore utilized to screen a human cardiac cDNA-library (~107 primary clones) in C2C12 cells through serial dilutions until single clones could be identified. This extensive screening strategy culminated in the identification of SUMO2 as a most efficient...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mice, Transgenic

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Share to Small Ubiquitin-Related Modifier Proteins

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Source

Open in PubMed Open full text

Identifiers

PMID: 27767176
DOI: 10.1038/srep35758
PMCID: PMC5073337

Genes

SUMO2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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