Article

Elevated somatic mutation burdens in normal human cells due to defective DNA polymerases

2020-06-24

Abstract excerpt

<h4>ABSTRACT</h4> Mutation accumulation over time in normal somatic cells contributes to cancer development and is proposed as a cause of ageing. DNA polymerases Pol ε and Pol δ replicate DNA with high fidelity during normal cell divisions. However, in some cancers defective proofreading due to acquired mutations in the exonuclease domains of POLE or POLD1 causes markedly elevated somatic mutation burdens with di...

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Literature Corpus work: 3d670611-f9c7-52ee-90d6-915b66b9ac1e
DOI: 10.1101/2020.06.23.167668

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