Article
Expression of the cancer-associated DNA polymerase ε P286R in fission yeast leads to translesion synthesis polymerase dependent hypermutation and defective DNA replication.
PLoS genetics - 1 Jul 2021
Soriano Ignacio, Vazquez Enrique, De Leon Nagore, Bertrand Sibyl, Heitzer Ellen, Toumazou Sophia, Bo Zhihan, Palles Claire, Pai Chen-Chun, Humphrey Timothy C, Tomlinson Ian, Cotterill Sue, Kearsey Stephen E
Abstract excerpt
Somatic and germline mutations in the proofreading domain of the replicative DNA polymerase ε (POLE-exonuclease domain mutations, POLE-EDMs) are frequently found in colorectal and endometrial cancers and, occasionally, in other tumours. POLE-associated cancers typically display hypermutation, and a unique mutational signature, with a predominance of C > A transversions in the context TCT and C > T transitions in...
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