Article

Generalizable and scalable protein stability prediction with rewired protein generative models

2025-02-18

Abstract excerpt

Predicting changes in protein thermostability caused by amino acid substitutions is essential for understanding human diseases and engineering proteins for practical applications. While recent protein generative models demonstrate impressive zero-shot performance in predicting various protein properties without task-specific training, their strong unsupervised prediction ability remains underexploited to improve p...

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Literature Corpus work: 39770625-65b5-5c33-9d56-10e16a26212c
DOI: 10.1101/2025.02.13.638154

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