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Article

Generalizable and scalable protein stability prediction with rewired protein generative models.

Nature communications - 20 Dec 2025

Li Ziang, Luo Yunan

Abstract excerpt

Predicting changes in protein thermostability caused by amino acid substitutions is essential for understanding human diseases and engineering proteins for practical applications. While recent protein generative models demonstrate impressive zero-shot performance in predicting various protein properties without task-specific training, their strong unsupervised prediction ability remains underexploited to improve...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41422228
DOI: 10.1038/s41467-025-67609-4
PMCID: PMC12830971

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