Article

Tolerance of nonsynonymous variation is closely correlated between human and mouse orthologues

2019-06-03

Abstract excerpt

<h4>ABSTRACT</h4> Genic constraint describes how tolerant a gene is of nonsynonymous variation before it is removed from the population by negative selection. Here, we provide the first estimates of intraspecific constraint for mouse genes genome-wide, and show constraint is positively correlated between human and mouse orthologues (r = 0.806). We assess the relationships between mouse gene constraint and knockou...

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Literature Corpus work: d62c99b2-dbac-5f4f-a816-be5159e6733b
DOI: 10.1101/657981

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