Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Natural selection on genes that underlie human disease susceptibility.

Current biology : CB - 24 Jun 2008

Blekhman Ran, Man Orna, Herrmann Leslie, Boyko Adam R, Indap Amit, Kosiol Carolin, Bustamante Carlos D, Teshima Kosuke M, Przeworski Molly

Abstract excerpt

What evolutionary forces shape genes that contribute to the risk of human disease? Do similar selective pressures act on alleles that underlie simple versus complex disorders [1-3]? Answers to these questions will shed light onto the origin of human disorders (e.g., [4]) and help to predict the population frequencies of alleles that contribute to disease risk, with important implications for the efficient design...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Computational Biology
Share to Databases, Factual

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Diseases, Inborn

Share to Genome, Human

Share to Polymorphism, Genetic

Share to Selection, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 18571414
DOI: 10.1016/j.cub.2008.04.074
PMCID: PMC2474766

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Natural selection on genes that underlie human disease susceptibility.PMID 18571414Read ↗

Properties of human disease genes and the role of genes linked to Mendelian disorders in complex disease aetiology.Semantic proximity Read ↗

Population history and natural selection shape patterns of genetic variation in 132 genes.Semantic proximity Read ↗

Mutation-selection-drift balance models of complex diseasesSemantic proximity Read ↗

Coding single-nucleotide polymorphisms associated with complex vs. Mendelian disease: evolutionary evidence for differences in molecular effects.Semantic proximity Read ↗

Are rare variants responsible for susceptibility to complex diseases?Semantic proximity Read ↗

Differences in the evolutionary history of disease genes affected by dominant or recessive mutations.Semantic proximity Read ↗

Mutation-selection-drift balance models of complex diseases.Semantic proximity Read ↗

Overcoming constraints on the detection of recessive selection in human genes from population frequency data.Semantic proximity Read ↗

Recent human evolution has shaped geographical differences in susceptibility to disease.Semantic proximity Read ↗

Evolutionary profiling reveals the heterogeneous origins of classes of human disease genes: implications for modeling disease genetics in animalsSemantic proximity Read ↗

Overcoming constraints on the detection of recessive selection in human genes from population frequency dataSemantic proximity Read ↗

Genetic variation and adaptation in Africa: implications for human evolution and disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.