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Article

Inferring nonneutral evolution from human-chimp-mouse orthologous gene trios.

Science (New York, N.Y.) - 12 Dec 2003

Clark Andrew G, Glanowski Stephen, Nielsen Rasmus, Thomas Paul D, Kejariwal Anish, Todd Melissa A, Tanenbaum David M, Civello Daniel, Lu Fu, Murphy Brian, Ferriera Steve, Wang Gary, Zheng Xianqgun, White Thomas J, Sninsky John J, Adams Mark D, Cargill Michele

Abstract excerpt

Even though human and chimpanzee gene sequences are nearly 99% identical, sequence comparisons can nevertheless be highly informative in identifying biologically important changes that have occurred since our ancestral lineages diverged. We analyzed alignments of 7645 chimpanzee gene sequences to their human and mouse orthologs. These three-species sequence alignments allowed us to identify genes undergoing...

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PMID: 14671302
DOI: 10.1126/science.1088821

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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