Article

Implications of simplified linkage equilibrium SNP simulation

2015-08-27

Abstract excerpt

In a recent paper published in PNAS (Golan et al. 2014), residual maximum likelihood (REML) seriously underestimated genetic variance explained by genomewide single nucleotide polymorphism when using a case-control design. It was concluded that Haseman–Elston regression (denoted as PCGC in their paper) should be used instead of REML. Their conclusions were based on results from simplified linkage equilibrium SNP s...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d6290f73-eb9f-599c-a877-cd6529c95a64
DOI: 10.1101/025619

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Implications of simplified linkage equilibrium SNP simulationDOI 10.1101/025619Read

Reply to Lee: Downward bias in heritability estimation is not due to simplified linkage equilibrium SNP simulation.Semantic proximity Read

Non-linear randomized Haseman-Elston regression for estimation of gene-environment heritabilitySemantic proximity Read

Quantitative trait linkage analysis by generalized estimating equations: unification of variance components and Haseman-Elston regression.Semantic proximity Read

The Garden of Forking Paths: Reinterpreting Haseman-Elston Regression for a Genotype-by-Environment Model.Semantic proximity Read

Design and analysis of genetic association studies to finely map a locus identified by linkage analysis: assessment of the extent to which an association can account for the linkage.Semantic proximity Read

Genome simulation approaches for synthesizing in silico datasets for human genomics.Semantic proximity Read

Linkage analysis of a derived glucose phenotype in the Genetic Analysis Workshop 13 simulated data using a variety of Haseman-Elston based regression methods.Semantic proximity Read

Linear regression in genetic association studies.Semantic proximity Read

Comparison of Haseman-Elston regression analyses using single, summary, and longitudinal measures of systolic blood pressure.Semantic proximity Read

Equivalence between Haseman-Elston and variance-components linkage analyses for sib pairs.Semantic proximity Read

Comparison of marker intervals and number of sib pairs used for linkage analysis on simulated nuclear family data.Semantic proximity Read

Impact of preadjusting a quantitative phenotype prior to sib-pair linkage analysis when gene x environment interaction exists.Semantic proximity Read