Article

Overeating in the Ts65Dn trisomic mouse model is associated with dopaminergic neurotransmission deficit in the prefrontal cortex

2022-12-22

Abstract excerpt

<title>Abstract</title> <p>Individuals with Down syndrome (DS) have a higher prevalence of obesity than the general population. This has traditionally been attributed to endocrine issues and deficient exercise. However, the development of obesity is coupled with deficits in neural reward responses, and previous works showed dopaminergic disturbances in DS. We here tested the hypothesis that “hedonic” overeating m...

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Literature Corpus work: d610ab72-2ef0-5925-a304-0a27ecdab99e
DOI: 10.21203/rs.3.rs-2358600/v1

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