Article

Suppressor of Cytokine Signaling 3 Derived Peptide as a Therapeutic for Inflammatory, and Oxidative Stress Induced Damage to the Retina

2023-09-06

Abstract excerpt

<h4>Purpose</h4> Inflammation and oxidative stress are contributing factors to age-related macular degeneration (AMD) and other retinal diseases. We tested a cell penetrating peptide from the kinase inhibitory region of intracellular checkpoint inhibitor Suppressor of Cytokine Signaling 3 (R9-SOCS3-KIR) peptide for its ability to blunt the inflammatory or oxidative pathways leading to AMD. <h4>Methods</h4> We us...

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Literature Corpus work: d607c945-45e5-55cf-acea-eb428b619a2a
DOI: 10.1101/2023.09.04.556227

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