Article

A molecular network of the aging brain implicates <i>INPPL1</i> and <i>PLXNB1</i> in Alzheimer’s disease

2017-10-19

Abstract excerpt

The fact that only symptomatic therapies of small effect are available for Alzheimer’s disease (AD) today highlights the need for new therapeutic targets with which to prevent a major contributor to aging-related cognitive decline. Here, we report the construction and validation of a molecular network of the aging human frontal cortex. Using RNA sequence data from 478 individuals, we first identify the role of mod...

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Literature Corpus work: d60597e6-73cb-5e84-87c2-e2e23a01f577
DOI: 10.1101/205807

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