Article

Isoconazole and Clemizole Hydrochloride Partially Reverse the Xeroderma Pigmentosum C Phenotype

2021-02-16

Abstract excerpt

<title>Abstract</title> <p>Xeroderma Pigmentosum protein C (XPC) is involved in recognition and repair of bulky DNA damage such as lesions induced by Ultra Violet (UV) radiation. <italic>XPC</italic>-mutated cells are, therefore, photosensitive and accumulate DNA damage leading to increased cancer incidence. Here, we performed a high-throughput screen to identify chemicals capable of normalizing the XP-C phenotyp...

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Literature Corpus work: d5ef814f-3c26-55a2-9d6e-4e5a211356b4
DOI: 10.21203/rs.3.rs-197694/v1

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