Article
Spotlight on 'xeroderma pigmentosum'.
Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology - 1 Jan 2013
Fassihi Hiva
Abstract excerpt
Xeroderma pigmentosum (XP) is a rare autosomal recessive disorder of DNA repair characterised by photosensitivity, progressive pigmentary change, and an increased incidence of ultraviolet (UV)-induced skin and mucous membrane cancers. Approximately 25% of XP patients also have progressive neurological degeneration. There are eight XP complementation groups (XP-A through to XP-G, and XP variant (XP-V)),...
Topics
- DNA Damage
- DNA Helicases
- DNA Repair
- DNA-Binding Proteins
- DNA-Directed DNA Polymerase
- Deoxyribonucleases
- Humans
- Mutation
- Skin Neoplasms
- Ultraviolet Rays
- Xeroderma Pigmentosum