Article

T-cell immunity induced by a nonadjuvanted HLA-restricted peptide COVID-19 vaccine

2024-05-31

Abstract excerpt

<title>Abstract</title> <p>During COVID-19 pandemic, cases of postvaccination infections and restored SARS-CoV-2 virus have increased after full vaccination, which might be contributed to by immune surveillance escape or virus rebound. Here, artificial linear 9-mer human leucocyte antigen (HLA)-restricted UC peptides were designed based on the well-conserved S2 region of the SARS-CoV-2 spike protein regardless of...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d5ed922d-b72a-5cda-836c-c8c8186e1f37
DOI: 10.21203/rs.3.rs-4411027/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

T-cell immunity induced by a nonadjuvanted HLA-restricted peptide COVID-19 vaccineDOI 10.21203/rs.3.rs-4411027/v1Read

T cell immunity of the nonadjuvanted HLA-restricted peptide COVID-19 vaccineSemantic proximity Read

Designing an efficient multi-epitope vaccine displaying interactions with diverse HLA molecules for an efficient humoral and cellular immune response to prevent COVID-19 infection.Semantic proximity Read

Cytotoxic T-cell-based vaccine against SARS-CoV2: a hybrid immunoinformatic approachSemantic proximity Read

Screening of HLA-A restricted T cell epitopes of SARS-CoV-2 and induction of CD8 <sup>+</sup> T cell responses in HLA-A transgenic miceSemantic proximity Read

Phase I Trial of a Multi-Peptide COVID-19 Vaccine for the Induction of SARS-CoV-2 T-Cell ImmunitySemantic proximity Read

Bioinformatics Prediction and Identification of Sars-Cov-2-Derived Hla-a-Binding T Cell EpitopesSemantic proximity Read

CD8+ T Cell Epitope Variations Suggest a Potential Antigen Presentation Deficiency for Spike Protein of SARS-CoV-2Semantic proximity Read

T cell-mediated protection against lethal SARS-CoV-2 challenge by a synthetic long peptide vaccine targeting conserved CD4+ and CD8+ T cell epitopesSemantic proximity Read

Highly conserved, non-human-like, and cross-reactive SARS-CoV-2 T cell epitopes for COVID-19 vaccine design and validationSemantic proximity Read

Scrutinizing the SARS-CoV-2 protein information for the designing an effective vaccine encompassing both the T-cell and B-cell epitopesSemantic proximity Read

Design and Immune Profile of Multi-Epitope Synthetic Antigen Vaccine Against SARS-CoV-2: An In Silico and In Vivo ApproachSemantic proximity Read

Identification of a promiscuous conserved CTL epitope within the SARS-CoV-2 spike proteinSemantic proximity Read