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Screening of HLA-A restricted T cell epitopes of SARS-CoV-2 and induction of CD8 <sup>+</sup> T cell responses in HLA-A transgenic mice

2021-04-01

Abstract excerpt

While SARS-CoV-2-specific T cells have been characterized to play essential roles in host immune protection in COVID-19 patients, few researches focus on the functional validation of T cell epitopes and development of vaccines inducing specific T cell responses. In this study, 120 CD8 + T cell epitopes from E, M, N, S and RdRp proteins were validated. Among them, 110 epitopes have not been reported previously; 11...

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Literature Corpus work
17ca7175-8926-5ee1-931d-9714be676878
DOI
10.1101/2021.04.01.438020
Open publication

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Screening of HLA-A restricted T cell epitopes of SARS-CoV-2 and induction of CD8 <sup>+</sup> T cell responses in HLA-A transgenic miceDOI 10.1101/2021.04.01.438020
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