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Design and Immune Profile of Multi-Epitope Synthetic Antigen Vaccine Against SARS-CoV-2: An In Silico and In Vivo Approach

31 Jan 2025

Abstract excerpt

BACKGROUND: The rapid advancement of the pandemic caused by SARS-CoV-2 and its variants reinforced the importance of developing easy-to-edit vaccines with fast production, such as multi-epitope DNA vaccines. The present study aimed to construct a synthetic antigen multi-epitope SARS-CoV-2 to produce a DNA vaccine. METHODS: A database of previously predicted Spike and Nucleocapsid protein epitopes was created, and...

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PMID: 40006696
DOI: 10.3390/vaccines13020149

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