Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

STAT3/p53 pathway activation disrupts IFN-β–induced dormancy in tumor-repopulating cells

11 Feb 2018

Abstract excerpt

Dynamic interaction with the immune system profoundly regulates tumor cell dormancy. However, it is unclear how immunological cues trigger cancer cell-intrinsic signaling pathways for entering into dormancy. Here, we show that IFN-β treatment induced tumor-repopulating cells (TRC) to enter dormancy through an indolamine 2,3-dioxygenase/kynurenine/aryl hydrocarbon receptor/p27-dependent (IDO/Kyn/AhR/p27-dependent)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Immunotherapy and Biomarkers
Share to Immune cells in cancer
Share to Immunotherapy and Immune Responses

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 29431732
DOI: 10.1172/jci96329

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

STAT3/p53 pathway activation disrupts IFN-β–induced dormancy in tumor-repopulating cellsPMID 29431732Read ↗

Unveiling the role of cellular dormancy in cancer progression and recurrenceSemantic proximity Read ↗

Midkine Drives Reawakening of Dormant Melanoma MetastasesSemantic proximity Read ↗

IFN-γ orchestrates tumor elimination, tumor dormancy, tumor escape, and progressionSemantic proximity Read ↗

Unveiling cancer dormancy: Intrinsic mechanisms and extrinsic forcesSemantic proximity Read ↗

Mechanisms of Cancer Cell Dormancy—Another Hallmark of Cancer?Semantic proximity Read ↗

Tumor Cell Dormancy: Threat or Opportunity in the Fight against CancerSemantic proximity Read ↗

Redox Control of the Dormant Cancer Cell Life CycleSemantic proximity Read ↗

Molecular Pathways: Niches in Metastatic DormancySemantic proximity Read ↗

The force awakens: metastatic dormant cancer cellsSemantic proximity Read ↗

The Problem of Cancer Dormancy: Understanding the Basic Mechanisms and Identifying Therapeutic OpportunitiesSemantic proximity Read ↗

Controversies in clinical cancer dormancySemantic proximity Read ↗

Tumor dormancy as an alternative step in the development of chemoresistance and metastasis - clinical implicationsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.