Article

Microparticle-delivered Cxcl9 prolongs Braf inhibitor efficacy in melanoma

2022-05-25

Abstract excerpt

<h4>ABSTRACT</h4> Patients with BRAF-mutant melanoma show significant responses to combined BRAF and MEK inhibition, but most relapse within 2 years. A major reservoir for drug resistance is minimal residual disease (MRD), comprised of drug-tolerant tumor cells laying in a dormant state. Towards exploiting potential therapeutic vulnerabilities of MRD, we established a genetically engineered mouse model of Braf V...

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Literature Corpus work: 4337ee32-0e61-5ee4-874c-1f28994abd3f
DOI: 10.1101/2022.05.24.493271

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