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AAV2 can replicate its DNA by a rolling hairpin or rolling circle mechanism, depending on the helper virus

9 Oct 2024

Abstract excerpt

Adeno-associated virus type 2 (AAV2) is a small, non-pathogenic, helper virus-dependent parvovirus with a single-stranded (ss) DNA genome of approximately 4.7 kb. AAV2 DNA replication requires the presence of a helper virus such as adenovirus type 5 (AdV5) or herpes simplex virus type 1 (HSV-1) and is generally assumed to occur as a strand-displacement rolling hairpin (RHR) mechanism initiated at the AAV2 3'...

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PMID: 39382273
DOI: 10.1128/jvi.01282-24

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