Article

JAK2 governs Transferrin Receptor 1 dynamics in mammalian cells

2025-11-20

Abstract excerpt

<title>Abstract</title> <p>The dysregulation of the JAK/STAT signalling pathway is implicated in various human cancers, influence cell proliferation, survival, and tumour development. Activating mutations in the JAK2 kinase have been linked with myeloproliferative neoplasms (MPNs), particularly polycythemia vera (PV), characterised by increased red blood cell mass in the bone marrow. The advent of JAK2 inhibitors...

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Literature Corpus work: d5ce5cc2-fc5a-536f-8345-bc7b12350c83
DOI: 10.21203/rs.3.rs-6116162/v1

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