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Stat5 regulates cellular iron uptake of erythroid cells via IRP-2 and TfR-1

12 Aug 2008

Abstract excerpt

Erythropoiesis strictly depends on signal transduction through the erythropoietin receptor (EpoR)-Janus kinase 2 (Jak2)-signal transducer and activator of transcription 5 (Stat5) axis, regulating proliferation, differentiation, and survival. The exact role of the transcription factor Stat5 in erythropoiesis remained puzzling, however, since the first Stat5-deficient mice carried a hypomorphic Stat5 allele,...

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PMID: 18694996
DOI: 10.1182/blood-2008-02-138339

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