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Article

Genome wide hypomethylation and youth-associated DNA gap reduction promoting DNA damage and senescence-associated pathogenesis

2022-10-18

Abstract excerpt

<h4>Background: </h4> Age-associated epigenetic alteration is the underlying cause of DNA damage in aging cells. Two types of youth-associated DNA-protection epigenetic marks, global methylation, and youth-associated genomic stabilization DNA gap (youth-DNA-gap) reduce when cell ages. The epigenomic mark reduction promotes DNA damage and accelerates aging hallmarks. While DNA hypomethylation destabilizes DNA by se...

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Literature Corpus work
d5b3c3b2-d29a-56a2-a7fd-c2ad1df45ca4
DOI
10.21203/rs.3.rs-2140452/v1
Open publication

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