Infectivity versus Seeding in Neurodegenerative Diseases Sharing a Prion-Like Mechanism

Abstract excerpt

Prions are considered the best example to prove that the biological information can be transferred protein to protein through a conformational change. The term "prion-like" is used to describe molecular mechanisms that share similarities with the mammalian prion protein self-perpetuating aggregation and spreading characteristics. Since prions are presumably composed only of protein and are infectious, the more...

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