Article

Intermittent Hypoxia Induces Cognitive Dysfunction and Hippocampal Gene Expression Changes in a Mouse Model of Obstructive Sleep Apnea

2025-06-27

Abstract excerpt

Obstructive sleep apnea syndrome (OSAS) is characterized by cycles of decreased blood oxygen saturation followed by reoxygenation due to transient apnea. Cognitive dysfunction is a complication of OSAS, but its mechanisms remain unclear. 8-week-old C57BL/6J mice were exposed to intermittent hypoxia (IH) to model OSAS, and cognitive function and hippocampal gene expression were analyzed. Three groups were maintaine...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d57ba3cf-e6d5-5753-a032-90fd6b5bef7e
DOI: 10.20944/preprints202506.2250.v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Intermittent Hypoxia Induces Cognitive Dysfunction and Hippocampal Gene Expression Changes in a Mouse Model of Obstructive Sleep ApneaDOI 10.20944/preprints202506.2250.v1Read

Intermittent Hypoxia Impairs Cognitive Function and Promotes Mitophagy and Lysophagy in Obstructive Sleep Apnea–Hypopnea Syndrome Rat ModelSemantic proximity Read

Programmed cell death in the cognitive impairment of obstructive sleep apneaSemantic proximity Read

Epigenetic alterations in obstructive sleep Apnea: a pooled analysis of DNA methylation profiles in humans and animal modelsSemantic proximity Read

Short-term exposure to intermittent hypoxia leads to changes in gene expression seen in chronic pulmonary diseaseSemantic proximity Read

Chronic intermittent hypoxia exposure induces a unique microglial transcriptome in 5XFAD miceSemantic proximity Read

Older adults at greater risk for Alzheimer’s disease show stronger associations between sleep apnea severity and verbal memorySemantic proximity Read

Epigenetics: A Potential Mechanism Involved in the Pathogenesis of Various Adverse Consequences of Obstructive Sleep ApneaSemantic proximity Read

Whole‐transcriptome sequencing identifies neuroinflammation, metabolism and blood–brain barrier related processes in the hippocampus of aged mice during perioperative periodSemantic proximity Read

Altered hippocampal transcriptome dynamics following sleep deprivationSemantic proximity Read

Mechanistic insights into sevoflurane-induced hippocampal neuronal damage and cognitive dysfunction through the NEAT1/Nrf2 signaling axis in aged ratsSemantic proximity Read

The Impact of Intermittent Hypoxia on Metabolism and CognitionSemantic proximity Read

Short-term exposure to intermittent hypoxia leads to changes in gene expression seen in chronic pulmonary diseaseSemantic proximity Read