Article

Single-cell brain expression–guided causal analysis identifies GFM1 as a protective factor in insomnia risk

2026-04-19

Abstract excerpt

<title>Abstract</title> <p> <bold>Background:</bold> Insomnia is a common and heritable neurological condition that lacks clearly defined causal molecular drivers. Identifying brain cell–specific genes with protective effects may uncover new therapeutic targets for sleep-related disorders. <bold>Methods:</bold> We integrated brain single-cell gene expression profiles with insomnia genome-wide association data...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: d570d7b9-a01f-5161-808d-610681dedc58
DOI: 10.21203/rs.3.rs-9371633/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Single-cell brain expression–guided causal analysis identifies GFM1 as a protective factor in insomnia riskDOI 10.21203/rs.3.rs-9371633/v1Read

A cross-tissue transcriptome-wide association study identifies new susceptibility genes for insomnia.Semantic proximity Read

Genome-wide meta-analysis of insomnia prioritizes genes associated with metabolic and psychiatric pathways.Semantic proximity Read

Genome-wide Analysis of Insomnia (N=1,331,010) Identifies Novel Loci and Functional PathwaysSemantic proximity Read

Genome-wide analysis of insomnia disorder.Semantic proximity Read

Elucidating the susceptibility genes between insomnia and migraine by integrating genetic data and transcriptomes.Semantic proximity Read

Inferring cell-type-specific causal gene regulatory networks during human neurogenesisSemantic proximity Read

A Combined Analysis of Genetically Correlated Traits Identifies Genes and Brain Regions for Insomnia.Semantic proximity Read

Localization of migraine susceptibility genes in human brain by single-cell RNA sequencing.Semantic proximity Read

Shared genetic liability and causal effects between major depressive disorder and insomnia.Semantic proximity Read

Integrative genomics analysis identifies five promising genes implicated in insomnia risk based on multiple omics datasets.Semantic proximity Read

Inferring cell-type-specific causal gene regulatory networks during human neurogenesis.Semantic proximity Read

Causal Relationship Between Epilepsy, Status Epilepticus and Sleep-Related Traits: A Bidirectional Mendelian Randomization StudySemantic proximity Read