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Article

A cross-tissue transcriptome-wide association study identifies new susceptibility genes for insomnia.

Journal of neurophysiology - 1 Feb 2025

Li Li, Wu Dongjin, Zhang Cuiping, Lai Xiaokun, Zhang Ruolan, Hu Shuhui, Ye Yifeng

Abstract excerpt

Despite a significant genetic component to insomnia (heritability: 22%-25%), the genetic loci that modulate insomnia risk remain limited. We used the Unified Test for Molecular Markers (UTMOST) for transcriptome-wide association studies (TWAS) across various tissues, integrating summary statistics from a Genome-Wide Association Study (GWAS) of 462,341 European participants with gene expression data from the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 39745514
DOI: 10.1152/jn.00490.2024

Genes

VRK2
MMRN1
SMAD2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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