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Article

Alpha 1 Antitrypsin-Deficient Macrophages Have Impaired Efferocytosis of Apoptotic Neutrophils.

Frontiers in immunology - 1 Jan 2020

Lee Jungnam, Lu Yuanqing, Oshins Regina, West Jesse, Moneypenny Craig G, Han Kyudong, Brantly Mark L

Abstract excerpt

Alpha 1 antitrypsin deficiency (AATD) is an autosomal co-dominant disorder characterized by a low level of circulating AAT, which significantly reduces protection for the lower airways against proteolytic burden caused by neutrophils. Neutrophils, which are terminally differentiated innate immune cells and play a critical role to clear pathogens, accumulate excessively in the lung of AATD individuals. The...

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Identifiers

PMID: 33329539
DOI: 10.3389/fimmu.2020.574410
PMCID: PMC7714766

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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