Article

Reducing CETP activity prevents memory decline in an Alzheimer’s disease mouse model

2024-11-07

Abstract excerpt

Epidemiological studies have shown that lower activity of the cholesteryl ester transfer protein (CETP) correlates with reduced Alzheimer’s disease (AD) risk. While small molecule CETP inhibitors like evacetrapib have previously been assessed for cardiovascular diseases, their involvement in AD has not been investigated. Here, we establish CETP as a novel pharmacological target for AD treatment. Using CETP transge...

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Literature Corpus work: d4b9bd1e-1e95-5873-8004-364873bf965f
DOI: 10.1101/2024.11.05.621935

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