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Article

Anacetrapib, but not evacetrapib, impairs endothelial function in CETP-transgenic mice in spite of marked HDL-C increase.

Atherosclerosis - 1 Feb 2017

Simic Branko, Mocharla Pavani, Crucet Margot, Osto Elena, Kratzer Adelheid, Stivala Simona, Kühnast Susan, Speer Thimoteus, Doycheva Petia, Princen Hans M, van der Hoorn Jose W, Jukema J Wouter, Giral Hector, Tailleux Anne, Landmesser Ulf, Staels Bart, Lüscher Thomas F

Abstract excerpt

BACKGROUND AND AIMS: High-density lipoprotein cholesterol (HDL-C) is inversely related to cardiovascular risk. HDL-C raising ester transfer protein (CETP) inhibitors, are novel therapeutics. We studied the effects of CETP inhibitors anacetrapib and evacetrapib on triglycerides, cholesterol and lipoproteins, cholesterol efflux, paraoxonase activity (PON-1), reactive oxygen species (ROS), and endothelial function...

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Source

Identifiers

PMID: 28152406
DOI: 10.1016/j.atherosclerosis.2017.01.011

Genes

CETP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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