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Mendelian randomization revealing the protective effect of sodium-glucose cotransporter 2 inhibition on prostate cancer with verified evidence from electronic healthcare and biological data

2023-10-13

Abstract excerpt

<h4>Background</h4> Observational studies indicated a decreased risk of prostate cancer by SGLT2 inhibitors, but high-quality evidence is lacking to make a clear conclusion. We evaluated the effect of SGLT2 inhibition on prostate cancer risk by triangulating evidence from three methods. <h4>Methods</h4> Genetic variants associated with HbA 1c levels (P<5×10 -8 ) in the genomic region of the target gene, SLC5A2 , w...

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Literature Corpus work
76e0c359-e1a6-5b1a-ab2e-66c3bd74f3e2
DOI
10.1101/2023.10.10.23296790
Open publication

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Mendelian randomization revealing the protective effect of sodium-glucose cotransporter 2 inhibition on prostate cancer with verified evidence from electronic healthcare and biological dataDOI 10.1101/2023.10.10.23296790
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