Back to search

Article

RESEARCH PROTOCOL: Large-scale evidence generation and evaluation across a network of databases for type 2 diabetes mellitus

2021-09-29

Abstract excerpt

<h4>Background</h4> Therapeutic options for type 2 diabetes mellitus (T2DM) have expanded over the last decade with the emergence of sodium-glucose co-transporter-2 (SGLT2) inhibitors and glucagon-like peptide-1 (GLP1) receptor agonists, which reduced the risk of major cardiovascular events in randomized controlled trials (RCTs). Cardiovascular evidence for older second-line agents, such as sulfonylureas, and dire...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
1a7be77a-3165-502d-9035-df1833c309bb
DOI
10.1101/2021.09.27.21264139
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
RESEARCH PROTOCOL: Large-scale evidence generation and evaluation across a network of databases for type 2 diabetes mellitusDOI 10.1101/2021.09.27.21264139
Comparative Effectiveness of Second-line Antihyperglycemic Agents for Cardiovascular Outcomes: A Large-scale, Multinational, Federated Analysis of the LEGEND-T2DM StudySemantic proximity
Heterogeneity of Treatment Effects of Glucose-lowering Drug Classes for Type 2 Diabetes: LEGEND-T2DM Network Real-World EvidenceSemantic proximity
Heterogeneity of Treatment Effects Across Nine Glucose-Lowering Drug Classes in Type 2 Diabetes: Extension of the LEGEND-T2DM Network StudySemantic proximity
Comparative cardiovascular safety of GLP-1 receptor agonists versus other glucose-lowering agents in real-world patients with type 2 diabetes: a nationwide population-based cohort studySemantic proximity
Cohort profile: The Nanjing Diabetes Cohort database – a population-based surveillance cohortSemantic proximity
Long-Term Efficacy and Safety of GLP-1R Agonist and SGLT2 Inhibitor Therapy in the General Population: A 2x2 Factorial Mendelian Randomization StudySemantic proximity
Systematic Review and Meta-Analysis Protocol of Type 1 Diabetes Registries: An Insight into Clinical and Epidemiological ObservationsSemantic proximity
Derivation and validation of a type 2 diabetes treatment selection algorithm for SGLT2-inhibitor and DPP4-inhibitor therapies based on glucose-lowering efficacy: cohort study using trial and routine clinical dataSemantic proximity
A reproducible open-source framework for defining type 1 and type 2 diabetes research cohorts in routinely collected electronic health record dataSemantic proximity
Rationale and design of the Brazilian Diabetes Study: a prospective cohort of type 2 diabetesSemantic proximity
Efficacy and Safety of SGLT2 Inhibitors in the Treatment of Type 2 Diabetes: An Umbrella ReviewSemantic proximity
A genetically supported drug repurposing pipeline for diabetes treatment using electronic health recordsSemantic proximity
Select a neighboring publication to make it the new centre.