Article
Performance of somatic structural variant calling in lung cancer using Oxford Nanopore sequencing technology.
BMC genomics - 30 Sept 2024
Liu Lingchen, Zhang Jia, Wood Scott, Newell Felicity, Leonard Conrad, Koufariotis Lambros T, Nones Katia, Dalley Andrew J, Chittoory Haarika, Bashirzadeh Farzad, Son Jung Hwa, Steinfort Daniel, Williamson Jonathan P, Bint Michael, Pahoff Carl, Nguyen Phan T, Twaddell Scott, Arnold David, Grainge Christopher, Simpson Peter T, Fielding David, Waddell Nicola, Pearson John V
Abstract excerpt
BACKGROUND: Lung cancer is a heterogeneous disease and the primary cause of cancer-related mortality worldwide. Somatic mutations, including large structural variants, are important biomarkers in lung cancer for selecting targeted therapy. Genomic studies in lung cancer have been conducted using short-read sequencing. Emerging long-read sequencing technologies are a promising alternative to study somatic...
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