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The <i>Toxoplasma</i> Oxygen Sensing Protein, TgPhyA, Is Required for Resistance to Interferon-gamma Mediated Nutritional Immunity

2023-05-16

Abstract excerpt

As Toxoplasma gondii disseminates through its host, the parasite must sense and adapt to its environment and scavenge nutrients. Oxygen (O 2 ) is one such environmental factor and cytoplasmic prolyl 4-hydroxylases (PHDs) are evolutionarily conserved O 2 cellular sensing proteins that regulate responses to changes in O 2 availability. Toxoplasma expresses two PHDs. One of them, TgPHYa hydroxylates SKP1, a subu...

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Identifiers and source

Literature Corpus work
d45a5239-963d-5d04-b332-0cbe52481f99
DOI
10.1101/2023.05.16.540931
Open publication

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The <i>Toxoplasma</i> Oxygen Sensing Protein, TgPhyA, Is Required for Resistance to Interferon-gamma Mediated Nutritional ImmunityDOI 10.1101/2023.05.16.540931
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