Article

Perturbed actin cap and nuclear morphology in primary fibroblasts of Huntington’s disease patients as a new phenotypic marker for personalized drug evaluation

2022-04-04

Abstract excerpt

Human primary skin fibroblast cells from patient’s skin biopsies were used previously as a model to study different neurodegenerative diseases, including Huntington’s Disease (HD). These cells are directly isolated from the patient’s tissue without any alteration in the genome, retaining in culture conditions their endogenous cellular characteristics and biochemical properties, as well as their cellular proliferat...

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Literature Corpus work: d41d7d3f-175b-5529-825e-1214b6516e11
DOI: 10.1101/2022.04.03.486386

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