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Article

High throughput quantification of mutant huntingtin aggregates.

Journal of neuroscience methods - 15 Jun 2008

Scotter Emma L, Narayan Pritika, Glass Michelle, Dragunow Mike

Abstract excerpt

Mutant protein aggregates are an important biomarker in Huntington's and other neurodegenerative diseases however their quantification has typically relied on manual imaging and counting, or cell-free assays, which do not allow for concurrent analysis of cell viability. Here we describe four automated high throughput image analysis methods, developed using Metamorph software, to quantify mutant huntingtin...

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Identifiers

PMID: 18367250
DOI: 10.1016/j.jneumeth.2008.02.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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